These are the list of questions you should think about.
1) When was the property built?
2) Any known natural disaster, or flooding that could have affected the foundation of the home?
3) Increase in property Value in the past 5-10 years?
4) How accessible is the area from the freeway?
5) How are the neighbours and the neighbourhood? The best time to shop for a home is in March and April, you will get a chance to see the type of people that live in the area more.
5) Depending on how old the house is, you might have to do alot of rewiring, changing the water heater and the air ventilation.
6) If there is an attic, you should ask about any infestations of animals such as Raccoons, Squirrels or any type of rodents.
7) The appliances in the home, the older they are the more money it will cost you to replace them.
8) Be prepared to get tricked but you can minimize how much you get tricked by going in with very high expectations and walking away with what you wanted to begin with, without having to spend more money.
Hope that helps, if you have any other questions, you can hit me up.